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Protein Design

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin

Submitted by admin on Thu, 2011-05-19 12:29
Authors: 
Fleishman SJ, Whitehead TA, Ekiert DC, Dreyfus C, Corn JE, Strauch EM, Wilson IA, Baker D
Volume: 
332
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/21566186
Year: 
2011
Reference: 
Science
Pages: 
816-21
Lab: 
Baker
Publication Type: 
Application
Publication Subject: 
Protein Design

Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interface.

Submitted by admin on Wed, 2011-04-06 07:33
Authors: 
Babor M, Mandell DJ, Kortemme T
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/21465611
Year: 
2011
Reference: 
Protein Sci
Publication Type: 
Application
Publication Subject: 
Protein Design
Lab: 
Kortemme

Tryptophanyl-tRNA synthetase Urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementation

Submitted by admin on Tue, 2011-04-05 00:42
Authors: 
Pham Y, Kuhlman B, Butterfoss GL, Hu H, Weinreb V, Carter CW Jr
Volume: 
285
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/20864539
Year: 
2010
Reference: 
J Biol Chem
Pages: 
38590-601
Lab: 
Kuhlman
Publication Type: 
Application
Publication Subject: 
Protein Design

3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators

Submitted by admin on Tue, 2011-04-05 00:13
Authors: 
Lowe EW Jr, Ferrebee A, Rodriguez AL, Conn PJ, Meiler J
Volume: 
20
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/20732812
Year: 
2010
Reference: 
ioorg Med Chem Lett
Pages: 
5922-4
Lab: 
Meiler
Publication Type: 
Application
Publication Subject: 
Protein Design

Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel

Submitted by admin on Tue, 2011-04-05 00:11
Authors: 
Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS
Volume: 
79
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/20926757
Year: 
2011
Reference: 
Mol Pharmacol
Pages: 
42-50
Lab: 
Meiler
Publication Type: 
Application
Publication Subject: 
Protein Design

Role of conformational sampling in computing mutation-induced changes in protein structure and stability

Submitted by admin on Sun, 2011-04-03 07:56
Authors: 
Kellogg EH, Leaver-Fay A, Baker D
Volume: 
79
Link to Article: 
http://www.ncbi.nlm.nih.gov/pubmed/21287615
Year: 
2011
Reference: 
Proteins
Pages: 
830-8
Lab: 
Baker
Publication Type: 
Application
Publication Subject: 
Protein Design

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